Fig. 3

The chromatin accessibility of introns and 2 kb upstream region are associated with var gene expression. a, b Vioplots show the FAIRE-Seq signals of different var gene regions that are classified based on gene expression data (Otto TD et al. RNA-Seq data [27]). c The bee swarm plot shows Pearson correlation value between FAIRE-Seq signal on different var 5′ upstream regions and var gene expression from three independent expression data sets. The median value and standard deviation is represented by the black bar (‘*’ represents Wilcoxon-Rank-Sum test p-value < 0.05 compared with the second most significant correlation value). d Scatterplot shows FAIRE-Seq signal around var intron and 2 kb upstream region. X-axis and Y-axis represent log(FAIRE-Seq RPKM) value on var 2 kb upstream and intron region. e The bee swarm plot shows FAIRE-Seq signal correlation value between different var regions and exon during ring and trophozoite stages (‘*’ represents Wilcoxon-Rank-Sum test p-value < 0.05 compared with second significant correlation value)