| Polyphen-2b
| SIFTc
|
---|
Chr | SNPa
| Gene symbol | Substitution | Prediction | Score | Prediction | Score |
---|
10 | g.62111230G > A |
FBN1
| p.V2290I | benign | 0 | tolerated | 0.36 |
10 | g.62382825G > A |
SLC12A1
| p.P372L | probably damaging | 0.993 | deleterious | 0 |
- Exome sequencing of two affected fetuses with homozygous risk-haplotype and two unaffected calves without risk-haplotype
-
aPositions are based on the UMD3.1 assembly of the bovine genome
-
bPolyphen-2 score represents the probability that a substitution is deleterious, with values nearer 1 indicating more confident predictions
-
cSIFT score is the normalized probability that a substitution is tolerated, with values nearer 0 being more likely to be deleterious