Skip to main content
Fig. 9 | BMC Genomics

Fig. 9

From: In vivo Ebola virus infection leads to a strong innate response in circulating immune cells

Fig. 9

Model for the expression of interferon-stimulated genes during Ebola virus infection. a Ebola-infected cell (top) is not able to produce interferon due to the VP35-inhibition of IRF3 translocation. We suggest that the infected cell, through an unknown mechanism, might be able to induce neighboring cells (middle) to translocate IRF3 to the nucleus and start producing interferon. Once interferon is released by the neighboring cells, it activates the receptors of additional cells (bottom) and leads to the transcription of ISGs. b An alternative model is that some cells (top) can become infected with Ebola VLPs, which are not able to block IRF3 translocation, and therefore they can produce interferon, release it to neighboring cells (middle and bottom) and they in turn start transcribing ISGs

Back to article page