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Fig. 3 | BMC Genomics

Fig. 3

From: CNARA: reliability assessment for genomic copy number profiles

Fig. 3

Five example specimen of copy number profiles for each of the reliability groups. 3a: Case 1, hyper-segmented, discernible CNAs with some waves; 3b: Case 2, reliable, discernible CNAs with few waves; 3c: Case 3, unreliable, indiscernible CNAs with heavy waves; 3d: Case 4, unreliable, large DLRS, undetectable CNAs; 3e: Case 5, reliable, control sample or without many CNAs. In each subgraph 3a to 3e, the upper panel shows the copy number profile segmented by the CBS algorithm, and the lower panel displays the same copy number profile segmented by step-fitting in the optimal iteration when S peak was attained, where the red line is the fit and the blue line is the counter-fit. In Fig. 3 f, S values are shown for the same five copy number profiles. For each curve the S-values for 120 iterations are shown. The GEO accession numbers [29] for the five cases are: Case 1, GSM360756 [30]; Case 2, GSM491138 [31]; Case 3, GSM360643 [30]; Case 4, GSM187938 [32]; and Case 5, GSM182894 [33]

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