Table 3 The power comparison of SKAT, SKAT-O, and AP-SKAT aimed at testing the association between randomly selected 5 kb regions and continuous traits under the effect size = 1.2
From: AP-SKAT: highly-efficient genome-wide rare variant association test
SKAT | SKAT-O | AP-SKAT | |||||||
|---|---|---|---|---|---|---|---|---|---|
|  | 10−2 | 10−3 | 10−4 | 10−2 | 10−3 | 10−4 | 10−2 | 10−3 | 10−4 |
250 | 1.01E-1 | 2.72E-2 | 7.04E-3 | 1.01E-1 | 2.75E-2 | 7.11E-3 | 1.03E-1 | 2.73E-2 | 7.42E-3 |
500 | 2.57E-1 | 1.04E-1 | 3.90E-2 | 2.59E-1 | 1.05E-1 | 3.94E-2 | 2.64E-1 | 1.06E-1 | 4.13E-2 |
750 | 4.16E-1 | 2.32E-1 | 1.07E-1 | 4.19E-1 | 2.34E-1 | 1.09E-1 | 4.21E-1 | 2.33E-1 | 1.12E-1 |
1000 | 5.06E-1 | 3.64E-1 | 2.18E-1 | 5.07E-1 | 3.64E-1 | 2.20E-1 | 5.11E-1 | 3.63E-1 | 2.18E-1 |
1250 | 5.79E-1 | 4.62E-1 | 3.36E-1 | 5.81E-1 | 4.64E-1 | 3.39E-1 | 5.83E-1 | 4.62E-1 | 3.37E-1 |
1500 | 6.68E-1 | 5.01E-1 | 4.29E-1 | 6.66E-1 | 5.01E-1 | 4.32E-1 | 6.72E-1 | 5.02E-1 | 4.28E-1 |