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Erratum to: The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies
BMC Genomics volume 17, Article number: 829 (2016)
The original article was published in BMC Genomics 2015 16:403
Please see modification to the first erratum  below, in which the Grant support section should have been modified as well:
Following the publication of our recent article in BMC Genomics  a number of aspects were called to our attention. We have carefully reviewed the experiments reported in this manuscript, additional data from our laboratories, as well as the content in Grant support section, and would like to make the following points:
SW-850, included in our paper as a bladder cancer cell line, has been reported by several authors to be a pancreatic cancer cell line [2–5]. This is unlikely to be the case given that most pancreatic cancers are KRAS-mutant and both our analysis and a previous publication  indicate that the cells used are KRAS-wild type. However, given the controversy we recommend that these cells are not be used as bladder cancer models.
The Materials and Methods section of our paper indicated that the following cell lines were obtained from ATCC: 253 J, 575A, 639 V, JON, MGH-U4, SW-800, SW-1710, VM-CUB-2. However, these cultures have never been distributed by the ATCC. Therefore, they are available from us if other investigators are interested in using them.
It has been reported that VM-CUB-3 is a VM-CUB-1 contaminant  [9, 10]. Nevertheless, our data indicate that the two cultures we used as VM-CUB-1 and VM-CUB-3 are distinct at the genomic level. Furthermore, as shown in Table 1, fingerprinting analysis clearly indicates that VM-CUB-1, VM-CUB-2, and VM-CUB-3 are different from each other. The origin of the DNA/cells in our paper was as indicated in the Material and Methods section and, therefore, investigators interested in these cells could directly address the corresponding co-authors.
In the last few years there has been much emphasis on the need to accurately designate, identify, and characterize cancer cell lines as they are precious tools for cell biology studies [11, 12]. It is with this aim that we wish to make these comments and clarifications related to our recently published work.
This work was supported, in part, by the Spanish Ministry of Economy and Competitivenes (MINECO) grants Consolider ONCOBIO CSD2007-00017, SAF2011-15934-E, the Institute of Health Carlos III through the Red Temática de Investigación Cooperativa en Cáncer (RTICC)] with reference number RD12/0036/0034, which is cofunded by European Regional Development Fund (ERDF); Asociación Española Contra el Cáncer, the project UROMOL EU-FP7-201663, and National Institutes of Health grants (NIH) grants RO1-CA089715; and CA075115 and CA104106 (to D.T.).
Earl J, Rico D, Carrillo-de-Santa-Pau E, Rodríguez-Santiago B, Méndez M, Auer H, et al. Erratum to: The UBC-40 Urothelial Bladder Cancer Cell Line Index: a genomic resource for functional studies. BMC Genomics. 2015;16:1019.
Earl J, Rico D, Carrillo-de-Santa-Pau E, Rodríguez-Santiago B, Méndez M, Auer H, et al. The UBC-40 Urothelial Bladder Cancer Cell Line Index: a genomic resource for functional studies. BMC Genomics. 2015;16:403.
Fogh J, Fogh JM, Orfeo T. One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J Natl Cancer Inst. 1977;59(1):221–6.
Fogh J, Wright WC, Loveless JD. Absence of HeLa cell contamination in 169 cell lines derived from human tumors. J Natl Cancer Inst. 1977;58(2):209–14.
Kalthoff H, Schmiegel W, Roeder C, Kasche D, Schmidt A, Lauer G, et al. p53 and K-RAS alterations in pancreatic epithelial cell lesions. Oncogene. 1993;8(2):289–98.
Müller C, Bockhorn AG, Klusmeier S, Kiehl M, Roeder C, Kalthoff H, et al. Lovastatin inhibits proliferation of pancreatic cancer cell lines with mutant as well as with wild-type K-ras oncogene but has different effects on protein phosphorylation and induction of apoptosis. Int J Oncol. 1998;12(3):717–23.
Freedman LP, Gibson MC, Ethier SP, Soule HR, Neve RM, Reid YA. Reproducibility: changing the policies and culture of cell line authentication. Nat Methods. 2015;12(6):493–7.
Yu M, Selvaraj SK, Liang-Chu MM, Aghajani S, Busse M, Yuan J, et al. A resource for cell line authentication, annotation and quality control. Nature. 2015;520(7547):307–11.
The online version of the original article can be found under doi:10.1186/s12864-015-1450-3.
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Earl, J., Rico, D., Carrillo-de-Santa-Pau, E. et al. Erratum to: The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies. BMC Genomics 17, 829 (2016) doi:10.1186/s12864-016-3179-z