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Table 2 Characteristics of putative G-quadruplex-forming sequences in the P. falciparum 3D7 genome

From: Recombination events among virulence genes in malaria parasites are associated with G-quadruplex-forming DNA motifs

PQS group

Total # PQSs in group

# PQSs with total loop length ≤7

# of 1 or 2 nucleotide loops

# single pyrimidine (not purine) loops

# PQSs with a longest-central loop

1 nt

2 nt

Var-associated

35

2 (5.7 %)

4 (3.8 %)

4 (3.8 %)

4 (3.8 %)

23 (65.7 %)

Non-var-associated

45

13 (28.9 %)

23 (17.0 %)

18 (13.3 %)

2 (1.5 %)

9 (20 %)

Total

80

15 (18.8 %)

27 (11.3 %)

22 (9.2 %)

6 (2.5 %)

32 (40 %)

Signif. difference?

 

Y

Y

N

Y

p-value

 

0.0095

<0.0001

0.3959

<0.0001

  1. Var-associated and non-var-associated groups of PQSs were scored for the four characteristics predicted to be G4-stabilizing: the table shows the number of PQSs in each group showing each characteristic. Differences between the scores for the two groups were assessed by Fisher’s exact test (2-tailed)
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BMC Genomics

ISSN: 1471-2164

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