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Table 4 Locations of PQS in the genomes of P. falciparum, P. reichenowi and P. berghei

From: Recombination events among virulence genes in malaria parasites are associated with G-quadruplex-forming DNA motifs

  

Genome

 

P. falciparum 3D7

P. reichenowi CDC

P. berghei ANKA

All PQS

   

 Within a gene

34

40

11

 Upstream (within 2 kb)

37

5

30

 Downstream (within 2 kb)

7

8

7

 No gene within 2 kb

2

0

0

 Total

80

53

48

Var-associated PQS

 Within a var gene

19

33 (inc. 1 pseudogene)

 

 Upstream (within 2 kb)

16

0

 

 Downstream (within 2 kb)

0

0

 

 Total var sequences

103a

103a

 

  Var genes

63a

64a

 

 Fragments/pseudogenes

6/34a

37/22a

 

Pir-associated PQS

 Within a pir gene

3

0

0

 Upstream (within 2 kb)

0

1

28

 Downstream (within 2 kb)

0

1

6

 Total pir sequences

226a

528a

299

  Pir genes

189a

351a

217

 Fragments/pseudogenes

0/37a

118/59a

0/82

  1. Table shows numbers of PQS found in each Plasmodium genome analysed. ‘Fragments/pseudogenes’ refers to the numbers of incomplete, but recognizable, var gene sequences, which are designated as gene fragments or pseudogenes
  2. aIndicates gene numbers taken from Otto et al. [31]