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Fig. 5 | BMC Genomics

Fig. 5

From: Mergeomics: multidimensional data integration to identify pathogenic perturbations to biological systems

Fig. 5

Performance comparison between wKDA and the unweighted key driver analysis. Two empirical subnetworks (Lipid I & II) were obtained from a previous publication [23], and a canonical metabolism of lipids and lipoproteins pathway was obtained from the Reactome database (R-HSA-556833). The methods were tested by projecting the three functional subnetworks onto two independent adipose networks (a–c) and two independent liver regulatory networks (d–f). The adipose and liver networks were constructed from a collection of Bayesian tissue-specific network models (Additional file 1: Table S3). Overlap between the tissue-specific key driver signals across two independent regulatory networks was defined according to the Jaccard index. Overlap ratio was calculated for both original networks and networks with 25, 50, 75 or 100 % rewiring of edges

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