Fig. 6

Visualization of adipose (a) and liver (b) networks around top key drivers that were identified for cholesterol-associated subnetworks. Top key drivers (nodes with the largest size) are selected as the top five independent key regulatory genes (genes whose neighbourhood has less than 25 % overlap with the neighbourhood of other independent hubs) for subnetwork 2 and subnetwork 6. Subnetwork member genes are denoted as medium size nodes and non-member genes as small size nodes. Top co-hubs (co-hubs with FDR < 10⁻¹⁰ in wKDA) are highlighted by yellow circles. Only edges that were supported by at least two studies are drawn