Subnetworks | −log10 P | Functional annotation | Top adipose KDs | Top liver KDs | ||||
---|---|---|---|---|---|---|---|---|
Key driver | −log10 P | Co-hubs | Key driver | −log10 P | Co-hubs | |||
Subnetwork 1 Lipoprotein | 16.0 | Lipid transport; cholesterol metabolism; lipoprotein; blood plasma | - | - | - | SPRY4 | 9.5 | ABCG8 |
S100A10 | 4.5 | - | ||||||
Subnetwork 2 Lipid metabolism | 8.1 | Lipid metabolism; metalloprotein; oxidoreductase; endoplasmic reticulum | ACADVL | 33.7 | PPARA, CIDEA | FASN | 49.0 | GPAM, ACLY |
FASN | 26.8 | ME1, ACSS2, ACLY, ELOVL6 | SQLE | 37.4 | FDFT1, IDI1, MSMO1, NSDHL, HMGCS1, ALDOC | |||
SCD | 24.0 | DNMT3L | DHCR7 | 26.9 | PMVK, MUM1, FDPS, LSS, RDH11, MVD | |||
CCBL2 | 23.3 | - | HSD17B7 | 23.9 | - | |||
ACO2 | 23.0 | AV075202, GPD2, NDUFV1 | MMT00007490 | 18.8 | HMGCR, LSS, FDFT1, MVD, ACSL3 | |||
Subnetwork 3 Immunoglobulin | 6.1 | Immunoglobulin V-set | COL1A1 | 12.4 | - | COL6A3 | 21.4 | - |
COL1A2 | 9.4 | COL3A1,COL2A1, MFAP2 | VIM | 11.0 | - | |||
OLFML3 | 8.8 | - | CCDC3 | 10.4 | OLFML3 | |||
POSTN | 8.3 | COL2A1 | CXCR7 | 9.9 | - | |||
FN1 | 7.2 | - | FBLN2 | 9.0 | - | |||
Subnetwork 4 ABC transport | 5.0 | ATP-binding cassette genes | - | - | - | SPRY4 | 12.0 | ABCG8 |
MMT00062095 | 4.3 | - | ||||||
S100A10 | 3.2 | - | ||||||
Subnetwork 5 Retinoid metabolism | 4.5 | Retinoid metabolism; Visual transduction | - | - | - | GC | 11.2 | RBP4,APOH |
TFPI2 | 3.2 | - | ||||||
AQP8 | 2.9 | - | ||||||
Subnetwork 6 Transcription | 3.8 | Transcription regulation; fatty acid metabolism; acyltransferase | SLC2A5 | 18.2 | - | PKLR | 23.6 | MMT00060232, ELOVL6 |
ACADVL | 17.7 | PPARA, CIDEA | PNPLA5 | 19.0 | ACLY, ACACA, PNPLA3 | |||
CPT2 | 15.9 | - | PGD | 12.2 | - | |||
EHHADH | 15.1 | - | FASN | 11.6 | GPAM,ACLY | |||
ACO2 | 13.7 | AV075202, GPD2, NDUFV1 | INSIG1 | 10.7 | - |