Table 5 Summary of the largest effect QTL detected for ADG in U.S. Angus, Hereford, and SimAngus beef cattle
From: Genome-wide association study for feed efficiency and growth traits in U.S. beef cattle
ADG | Position (Chr_Mb) | -log10 P-value | Regression Beta | PVE | Proximal/Putative Candidate Gene(s) | Scientific Precedence [reference]; organism; trait |
|---|---|---|---|---|---|---|
Angus | 9_93 | 6.16 | −0.11 | 0.017 | NOX3 | [95]; mice, human; insulin resistance |
15_79 | 5.57 | −0.10 | 0.015 | OR4X1 | ||
4_69 | 5.22 | 0.11 | 0.014 | SKAP2/LOC101903616 | [97]; human; diabetes | |
7_26 | 5.20 | −0.09 | 0.014 | SLC12A2/ADAMTS19/SLC27A6 | [11, 98, 99]; cattle, human, cattle; feed efficiency, interaction with IGF2R, fatty acid composition in bovine milk | |
3_82 | 5.10 | −0.10 | 0.013 | PGMI | [100]; pig; feed efficiency | |
6_16 | 4.64 | 0.10 | 0.012 | PITX2/EGF | [101, 102]; human, rabbit; adipogenesis, regulated absorption of nutrients | |
Hereford | 5_106 | 6.64 | −0.18 | 0.031 | FGF6/CCDN2/FGF23 | [103,104,105]; cattle, human; muscle mass in carcass, cell cycle regulation, insulin resistance and obesity |
7_93 | 6.51 | −0.15 | 0.031 | ARRDC3 | [106]; human, mice; body mass and energy expenditure | |
8_1 | 6.17 | 0.17 | 0.029 | PALLD | [107]; human; adipocyte size | |
8_4 | 4.96 | −0.15 | 0.023 | GALNTL6 | ||
8_2 | 4.82 | 0.13 | 0.022 | LOC511409/LOC101904351/LOC520638/AADAT | ||
1_144 | 4.71 | −0.45 | 0.021 | ABCG1/TFF3/TFF2/TFF1/UBASH3A | [112,113,114]; human, mice, pig; obesity, glucose tolerance, marbling score | |
2_23 | 4.53 | −0.25 | 0.021 | GPR155/SCRN3/SP9/OLA1 | [50; 116] pig, cattle; feed efficiency; infectious bovine keratoconjuctivitis | |
SimAngus | 27_26 | 5.93 | −0.15 | 0.019 | GTF2E2 | [117]; human; heart failure |
19_54 | 5.52 | 0.10 | 0.018 | DNAH17/RBFOX3 | [41]; human; adipogenic differentiation | |
13_53 | 4.87 | 0.16 | 0.016 | SNORA70/STK35/PDYN/SIRPA | [118,119,120,121]; human, cattle, mouse; diabetes, bovine liver prohormone, mouse feeding behavior and obesity traits, human adiposity | |
3_22 | 4.67 | −0.10 | 0.015 | LOC104971520/CHD1L/LOC788724/FMO5 | [88, 122, 123]; mice, human; obesity and diabetes, cellular proliferation | |
7_26 | 4.61 | 0.12 | 0.015 | ADAMTS19/SLC27A6 | [98, 99]; human, cattle; interaction with IGF2R, fatty acid composition in bovine milk | |
14_7 | 4.51 | −0.26 | 0.014 | LOC100848525/KHDRBS3 | ||
20_39 | 4.41 | 0.09 | 0.014 | RAI14 |