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Table 4 Genes with alleles specific to cluster 2 isolates

From: Hierarchical genomic analysis of carried and invasive serogroup A Neisseria meningitidis during the 2011 epidemic in Chad

Locus

Functional category

Number of mutation

Number of non-synonymous mutation

NEIS0370 (carA)

Metabolism (pyrimidine and alanine, aspartate and glutamate)

1 (bp 1057)

1 (T → A)a

NEIS0422 (metK)

Metabolism (cysteine and methionine metabolism)

1 (bp 726)

0

NEIS0529

Metal ions transport (zinc/manganese)

1 (bp 363)

0

NEIS1091 (cysl)

Metabolism (sulfite reductase)

1 (bp 1021)

1 (P → T)a

NEIS1237 (cmk)

Metabolism (pyrimidine)

1 (bp 611)

1 (I → T)a

NEIS1379 (dnaZX)

Metabolism/DNA processing

1 (bp 1774)

1 (G → S)a

NEIS1460

Putative metabolism (Glucose-6-Phosphate 1-Dehydrogenase_bact motif)

1 (bp 402)

0

NEIS1741 (murC)

Metabolism (D-glutamine/D-Glutamate, peptidoglycan biosynthesis)

1 (bp 397)

1 (A → S)a

NEIS1804

putative role in toxicity (associated with Maf Genomic islands MGI-1 scheme pubmlst)

1 (bp 868)

1 (F → V)

NEIS0132 (rplC)

Genetic information processing (ribosomal protein)

1 (bp 22)

1 (C → R)a

  1. aChange in the chemistry properties of the AA side chains