Long-lasting effect of obesity on skeletal muscle transcriptome

BMC Genomics

Table 2 The effect of CR on WSD-induced gene expression

Gene symbol	Description	Log_FC	P-Value	FDR
POSTN	Periostin, osteoblast specific factor	3.18	1.46E-06	0.0025
SMOC1	SPARC related modular calcium binding 1	1.97	1.30E-07	0.0005
MDK	Midkine (neurite growth-promoting factor 2)	1.82	1.11E-05	0.02
SFRP2	Secreted frizzled-related protein 2	1.48	2.80E-07	0.0006
AEBP1	AE binding protein 1	1.41	1.00E-06	0.002
PTGFR	Prostaglandin F receptor	1.31	2.72E-05	0.03
RRAD	Ras-related associated with diabetes	−1.57	1.61E-07	0.0005
TNFRSF12A	Tumor necrosis factor receptor superfamily 12A	−1.71	8.20E-08	0.0005
SERPINE1	Serpin peptidase inhibitor, clade E	−2.53	2.20E-05	0.03
CCDC81	Soiled-coil domain containing 81	−2.68	2.43E-08	0.0003

Soleus muscle biopsies were collected longitudinally, before WSD, 6 months after WSD, and 4 months after CR. Tissue samples were subjected to RNA extraction and RNAseq gene expression and bioinformatic analysis as described in “Materials and Methods”. Table shows upregulated and downregulated differentially expressed genes (DEGs) after CR in comparison with WSD (CR/WSD). Bioinformatic analysis was performed using FDR ≤ 0.05. Log_FC (fold change) was calculated as Log (FC, 2)

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