Table 2 Enrichment (GSEA) of top Hallmark Gene Sets for genes over- or underexpressed in the Scale-biter relative to all other taxa. Genes were pre-ranked by log2 fold change prior to analysis

Name

NES

Pvalue

FDR

Name

NES

Pvalue

FDR

Epith. Mesench. Trans.

2.80

0.00

0.00

E2F Targets

−3.60

0.00

0.00

Hypoxia

2.27

2.0E-03

0.01

Myc Targets V1

−3.23

0.00

0.00

Kras Signaling Dn

2.08

2.1E-03

0.02

Dna Repair

−3.06

0.00

0.00

Estrogen Resp. Early

1.87

0.01

0.07

G2M Checkpoint

−2.94

0.00

2.4E-04

Coagulation

1.86

0.01

0.06

Oxidative Phosph.

−2.60

0.00

8.8E-04

Tnfa Sig. via Nfkb

1.81

0.02

0.07

Myc Targets V2

−2.53

0.00

1.1E-03

Angiogenesis

1.64

0.04

0.14

Mitotic Spindle

-2.29

1.9E-03

3.6E-03

Myogenesis

1.64

0.03

0.12

Interferon Alpha Resp.

−1.83

0.01

0.04

P53 Pathway

1.58

0.06

0.14

Mtorc1 Signaling

−1.70

0.03

0.07

Kras Signaling Up

1.54

0.05

0.15

Fatty Acid Metabolism

−1.65

0.03

0.08

Name

NES

Pvalue

FDR

Name

NES

Pvalue

FDR

Myc Targets V1

2.69

0.00

1.2E-03

Bile Acid Metabolism

−2.59

0.00

2.0E-03

G2M Checkpoint

1.99

2.0E-03

0.07

Myogenesis

−2.44

0.00

3.8E-03

Androgen Response

1.69

0.03

0.21

Interferon Gamma Resp.

−2.01

0.01

0.05

E2F Targets

1.69

0.03

0.16

Interferon Alpha Resp.

−1.75

0.02

0.15

Myc Targets V2

1.68

0.03

0.13

Inflammatory Response

−1.68

0.03

0.18

Unfolded Protein Resp.

1.47

0.07

0.29

Adipogenesis

−1.66

0.03

0.16

Notch Signaling

1.44

0.10

0.28

Protein Secretion

−1.54

0.06

0.24

Heme Metabolism

1.40

0.11

0.29

Xenobiotic Metabolism

−1.51

0.07

0.24

Mtorc1 Signaling

1.25

0.18

0.47

Oxidative Phosphorylation

−1.43

0.10

0.30

Tnfa Signaling Via Nfkb

1.11

0.32

0.69

Kras Signaling Up

−1.41

0.10

0.28

Name

NES

Pvalue

FDR

Name

Nes

Pvalue

FDR

Uv Response Dn

2.25

0.00

0.02

E2F Targets

−5.90

0.00

0.00

Il2 Stat5 Signaling

2.14

0.01

0.02

G2M Checkpoint

−4.88

0.00

0.00

Kras Signaling Dn

2.12

0.00

0.01

Myc Targets V1

−4.18

0.00

0.00

Tnfa Signaling Via Nfkb

1.80

0.02

0.07

Oxidative Phosph.

−3.54

0.00

0.00

Angiogenesis

1.59

0.05

0.17

Mtorc1 Signaling

−3.42

0.00

0.00

Estrogen Response Early

1.58

0.04

0.15

Mitotic Spindle

−2.59

0.00

1.7E-04

Notch Signaling

1.54

0.06

0.16

Fatty Acid Metabolism

−2.37

0.00

2.3E-03

P53 Pathway

1.45

0.09

0.21

Dna Repair

−2.22

0.00

0.01

Apical Junction

1.45

0.09

0.18

Interferon Alpha Resp.

−1.82

0.02

0.05

Inflammatory Response

1.42

0.10

0.19

Glycolysis

−1.79

0.02

0.06

Name

NES

Pvalue

FDR

Name

NES

Pvalue

FDR

Inflammatory Response

2.25

2.0E-03

0.02

Oxidative Phosph.

−5.63

0.00

0.00

Cholesterol Homeostasis

2.13

2.1E-03

0.02

Myc Targets V1

−3.70

0.00

0.00

Wnt B-Catenin Signaling

2.02

3.9E-03

0.03

Fatty Acid Metabolism

−2.52

0.00

0.00

Hedgehog Signaling

1.94

0.01

0.04

Adipogenesis

−2.50

0.00

2.3E-04

Pi3K Akt Mtor Signaling

1.94

0.01

0.03

Dna Repair

−2.46

0.00

1.9E-04

Allograft Rejection

1.83

0.02

0.05

E2F Targets

−2.32

0.00

2.6E-03

Uv Response Dn

1.72

0.02

0.08

Bile Acid Metabolism

-2.19

1.9E-03

0.01

Complement

1.70

0.03

0.07

Tnfa Signaling Via Nfkb

−1.71

0.02

0.09

Estrogen Response Early

1.50

0.08

0.16

Xenobiotic Metabolism

−1.55

0.06

0.17

Apical Junction

1.41

0.10

0.23

Spermatogenesis

−1.51

0.07

0.19