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Fig. 1 | BMC Genomics

Fig. 1

From: The role of alternative Polyadenylation in regulation of rhythmic gene expression

Fig. 1

Molecular mechanism of a cellular circuit rectifier. a Two subpopulations of transcripts are created by occurrence of canonical distant PolyA signal and proximal non-canonical signal. b Transcription produces two types of mRNA that differ by a stretch of RNA that may contain functional sites such as microRNA target areas. Both transcripts share the same coding part. c When both transcripts have the same turnover rate, the transcript abundance has oscillating baseline. If more abundant transcript decays faster the peak abundance also shifts in time and can reach complete counter-phase (see Analytic Solution). In such case the sum of two transcripts approaches non-oscillatory steady line

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