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Table 1 Transcriptomic and proteomic analysis of the overlapped genes and their corresponding proteins in HBV (+) mouse

From: Proteomic and transcriptomic studies of HBV-associated liver fibrosis of an AAV-HBV-infected mouse model

 

Fold Change

 

Transcriptomic

Proteomic

protein

Gnen ID

Location

1 M

3 M

6 M

1 M

3 M

6 M

Function

Protein

ENSMUSG

00000038155

cytoplam;

4.70

8.8

8.27

N

up

N

dinitrosyl-iron complex binding; glutathione peroxidase activity; glutathione transferase activity; S-nitrosoglutathione binding

Gstp2

ENSMUSG

00000034456

cytosol

N

−2.55

−2.70

N

N

down

urocanatehydratase activity

Uroc1

ENSMUSG

00000074768

cytosol, extracellular

N

−8.56

−6.96

N

up

N

zinc ion binding, S-adenosylmethionine-homocysteine S-methyltransferase activity

Bhmt

ENSMUSG

00000039206

lysosome

N

−2.91

−2.65

N

N

up

metal ion binding, acylglycerol lipase activity

Daglb

ENSMUSG

00000026385

endoplasmic reticulum, extracellular

N

−3.00

−2.46

N

N

down

lipid binding

Dbi

ENSMUSG

00000033712

nuclear chromatin

N

−2.82

−3.30

N

N

down

RNA polymerase II core binding, enzyme inhibitor activity

Ccar2

ENSMUSG

00000032235

nucleus,

N

−2.46

−2.81

N

N

down

protein binding

Ice2

ENSMUSG

00000025950

cytosol, extracellular, peroxisome

N

−2.57

−2.05

N

N

down

isocitrate dehydrogenase (NADP+) activity

Idh1

ENSMUSG

00000031173

Mitochondrion

N

−3.42

−3.08

down

N

N

ornithine carbamoyltransferase activity

Otc

ENSMUSG

00000041268

extracellular

N

−2.80

−2.62

down

N

N

RabGTPase binding

Dmxl2

ENSMUSG

00000027187

cytosol, extracellular, peroxisome

N

−2.28

−2.00

N

down

N

antioxidant activity

Cat

ENSMUSG

00000046441

Nucleus. Cytoplasm.

N

−3.36

−3.90

N

N

down

mRNA (nucleoside-2-O-)-methyltransferase activity

Cmtr2

ENSMUSG

00000036591

cytoskeleton, golgi apparatus

N

−2.63

−3.54

N

N

down

GTPase activator activity

Arhgap21

ENSMUSG

00000021277

cytosol, mitochondrion

N

−2.81

−2.60

N

N

down

protein binding, tumor necrosis factor receptor binding

Traf3

ENSMUSG

00000030934

mitochondrion

N

−2.09

−3.03

N

down

N

ornithine-oxo-acid transaminase activity

Oat

ENSMUSG

00000055204

nucleus

N

4.41

3.712

N

up

up

chromatin binding

Ankrd17

ENSMUSG

00000071657

endoplasmic reticulum

N

2.88

3.53

N

N

up

protein binding

Bscl2

ENSMUSG

00000070390

cytosol, nucleus

N

8.16

5.02

N

N

up

protein binding

Nlrp1b

ENSMUSG

00000001674

nucleus

N

3.94

3.10

N

N

up

ATP binding, protein binding

Ddx18

ENSMUSG

00000040466

cytosol, extracellular, nucleus

N

2.35

3.03

N

N

up

biliverdinreductase activity, riboflavin reductase (NADPH) activity

Blvrb

ENSMUSG

00000020844

cytosol, nucleus

N

4.28

2.74

N

up

N

thioredoxin-disulfide reductase activity

Nxn

ENSMUSG

00000028163

cytosol, mitochondrion, nucleus

N

2.99

2.22

N

down

N

DNA binding

Nfkb1

ENSMUSG

00000024613

nucleus

N

6.15

5.93

N

up

N

skeletal system development

Tcof1

ENSMUSG

00000040940

cytosol,plasma membrane

N

2.87

2.24

N

N

down

protein binding, GTPase activator activity

Arhgef1

ENSMUSG

00000027840

extracellular

N

13.99

7.21

N

N

up

protein binding

wnt2b

ENSMUSG

00000055884

nucleus

5.70

N

−2.35

up

N

N

chromatin binding

Fancm

ENSMUSG

00000060803

Cytoplasm. Mitochondrion

N

N

−8.02

down

down

down

JUN kinase binding

Gstp1

ENSMUSG

00000041324

extracellular

N

N

4.30

N

up

N

cytokine activity

Inhba

  1. N: no difference
  2. up: up-regulated expression, compared with HBV(−) mouse
  3. down: down-regulated expression, compared with HBV(−) mouse