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Fig. 1 | BMC Genomics

Fig. 1

From: Robust mutant strain design by pessimistic optimization

Fig. 1

The pessimistic bi-level problem structure for knockout identification. The inner-most level problem defines the optimization of cell survival based on a specific cellular objective (e.g., maximization of biomass growth in P-OptKnock and minimization of flux changes in P-ROOM). The outer level maximizes the worst-case scenario for Succinate production

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