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Table 2 Knockout strains derived by pessimistic and optimistic models on the iAF1260 E.coli metabolic network

From: Robust mutant strain design by pessimistic optimization

  Knockouts   min vsuccinate max vsuccinate
ROOM -   0 0
FBA -   0 0.372
P-ROOM ∙ mlthf + nadp methf + nadph ε=0 8.09 8.09
  ∙ coa + pyr →accoa + for ε=1 5.69 40.08
  ∙ q8 + succ →fum + q8h2    
P-OptKnock ∙ mlthf + nadp methf + nadph ε=0 8.23 8.23
  ∙ coa + pyr →accoa + for ε=1 4.78 80.52
  ∙ q8 + succ →fum + q8h2    
ROOM ∙ g6p + nadp 6pgl + h + nadph ε=0 31.36 31.36
  ∙ h2o + pser-L →pi + ser-L ε=1 0 76.143
  ∙ q8 + succ →fum + q8h2    
OptKnock ∙ mlthf + nadp methf + nadph ε=0 8.23 8.23
  ∙ coa + pyr →accoa + for ε=1 4.78 80.52
  ∙ q8 + succ →fum + q8h2