Unique protein expression signatures of survival time in kidney renal clear cell carcinoma through a pan-cancer screening

Han, Guangchun; Zhao, Wei; Song, Xiaofeng; Kwok-Shing Ng, Patrick; Karam, Jose A.; Jonasch, Eric; Mills, Gordon B.; Zhao, Zhongming; Ding, Zhiyong; Jia, Peilin

doi:10.1186/s12864-017-4026-6

Table 3 Statistics of survival time prediction of KIRC stage-specific mRNA biomarkers

From: Unique protein expression signatures of survival time in kidney renal clear cell carcinoma through a pan-cancer screening

Gene	Protein	All stages			Stage I			Stage II			Stage III			Stage IV
Gene	Protein	p ^*	FDR	beta	p ^*	FDR	beta	p ^*	FDR	beta	p ^*	FDR	beta	p ^*	FDR	beta
KDR	VEGFR2	6.4 × 10⁻¹²	2.4 × 10⁻¹⁰	−0.39	0.09	0.42	−0.24	0.72	0.87	0.10	7.3 × 10 ⁻⁴	0.08	−0.35	4.3 × 10⁻⁴	7.5 × 10⁻³	−0.33
FASN	FASN	9.6 × 10⁻¹²	2.9 × 10⁻¹⁰	0.82	0.07	0.40	0.57	0.08	0.59	0.88	7.0 × 10⁻³	0.08	0.53	9.3 × 10 ⁻⁶	7.5 × 10⁻⁴	0.90
FOXM1	FoxM1	1.1 × 10⁻¹²	7.8 × 10⁻¹¹	0.49	0.10	0.42	0.32	0.15	0.71	0.40	0.13	0.35	0.18	1.0 × 10 ⁻⁵	7.5 × 10⁻⁴	0.51
CCNE1	Cyclin_E1	9.7 × 10⁻¹⁴	1.4 × 10⁻¹¹	0.58	0.02	0.33	0.46	0.03	0.52	0.76	0.09	0.30	0.23	3.4 × 10 ⁻⁵	1.7 × 10⁻³	0.54
ERBB3	HER3_pY128; HER3	1.4 × 10⁻⁷	1.1 × 10⁻⁶	−0.28	0.01	0.30	−0.34	0.24	0.78	−0.21	0.10	0.30	−0.18	2.0 × 10 ⁻⁴	6.2 × 10⁻³	−0.25
CCNE2	Cyclin_E2	3.2 × 10⁻⁵	1.4 × 10⁻⁴	0.47	0.88	0.98	0.04	0.09	0.59	0.69	0.85	0.92	0.04	2.5 × 10 ⁻⁴	6.2 × 10⁻³	0.70
BCL2	Bcl-2	4.9 × 10⁻⁸	4.5 × 10⁻⁷	−0.42	0.05	0.39	−0.30	0.62	0.87	0.16	0.04	0.18	−0.32	2.5 × 10 ⁻⁴	6.2 × 10⁻³	−0.48
ACACA	ACC_pS79; ACC1	2.8 × 10–5	1.3 × 10⁻⁴	0.61	0.05	0.39	0.61	0.65	0.87	0.24	0.04	0.19	0.53	4.3 × 10 ⁻⁴	7.5 × 10⁻³	0.82
DVL3	Dvl3	1.4 × 10⁻¹¹	3.3 × 10⁻¹⁰	1.22	0.01	0.30	1.14	0.01	0.52	1.40	7.5 × 10⁻³	0.08	0.84	4.6 × 10 ⁻⁴	7.5 × 10⁻³	1.09
COL6A1	Collagen_VI	1.5 × 10⁻⁹	2.5 × 10⁻⁸	0.50	0.21	0.71	0.28	0.18	0.71	0.30	5.4 × 10⁻³	0.08	0.45	5.6 × 10 ⁻⁴	8.0 × 10⁻³	0.41
CCNB1	Cyclin_B1	6.9 × 10⁻⁸	6.0 × 10⁻⁷	0.48	0.49	0.86	0.16	0.35	0.80	0.34	0.81	0.90	0.04	6.0 × 10 ⁻⁴	8.0 × 10⁻³	0.47
RAD51	Rad51	5.6 × 10⁻⁵	2.2 × 10⁻⁴	0.38	0.96	1.00	−0.01	0.14	0.71	0.42	0.42	0.66	−0.14	7.9 × 10 ⁻⁴	9.4 × 10⁻³	0.55
RB1	Rb_pS807_S811	2.9 × 10⁻⁶	1.8 × 10⁻⁵	−0.68	0.66	0.89	−0.19	0.05	0.52	−1.59	3.4 × 10⁻³	0.08	−0.60	8.7 × 10 ⁻⁴	9.4 × 10⁻³	−0.91
VHL	VHL	.07	0.11	0.22	0.34	0.84	0.26	0.18	0.71	0.61	0.53	0.74	−0.12	9.1 × 10 ⁻⁴	9.4 × 10⁻³	0.69
MYH11	MYH11	8.5 × 10⁻⁴	2.5 × 10⁻³	−0.16	0.38	0.85	−0.10	0.97	1.00	−7.4 × 10⁻³	0.16	0.38	−0.13	9.8 × 10 ⁻⁴	9.4 × 10⁻³	−0.22

*p-values were obtained using the log-rank test

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