Fig. 5
From: Genome-wide identification of key modulators of gene-gene interaction networks in breast cancer
Interaction among key modulator genes. a Heatmap of expression profiles of 973 modulator genes in the discovery dataset. Samples and genes were hierarchically clustered with average linkage. Though the modularity parameters were generally correlated, distinctive clusters of samples and modulators indicate the substantial differences and functions underlying the 973 identified modulators. b Histograms of the numbers of on-, off-, and all modulators in a sample. In average, 241.5 on- (with top 25% expression among samples, red line) and off- (bottom 25%, green) modulators were found in each sample. Collectively, 483 key modulators (49.6% of 973, blue) functioned as “effective” modulators in a sample