Genome-wide identification of key modulators of gene-gene interaction networks in breast cancer

BMC Genomics

Table 2 Top 6 clusters of GO terms enriched in SFRP1-modulated gene interaction network

GO ID	GO term	Num. genes	P-value
Cluster 1 (enrichment score: 10.71)
GO:0005578	proteinaceous extracellular matrix	75	1.68E-13
GO:0031012	extracellular matrix	78	3.84E-13
GO:0044420	extracellular matrix part	37	7.39E-11
GO:0005201	extracellular matrix structural constituent	27	2.93E-08
Cluster 2 (enrichment score: 7.13)
GO:0010033	response to organic substance	127	8.19E-12
GO:0009725	response to hormone stimulus	68	1.45E-07
GO:0048545	response to steroid hormone stimulus	42	6.50E-07
GO:0009719	response to endogenous stimulus	71	6.66E-07
GO:0043627	response to estrogen stimulus	27	4.33E-06
Cluster 3 (enrichment score: 6.56)
GO:0044421	extracellular region part	157	2.80E-12
GO:0005615	extracellular space	99	1.56E-05
GO:0005576	extracellular region	232	4.66E-04
Cluster 4 (enrichment score: 6.27)
GO:0007049	cell cycle	136	1.94E-12
GO:0022402	cell cycle process	104	6.36E-11
GO:0022403	cell cycle phase	78	7.27E-09
GO:0000279	M phase	61	6.77E-07
GO:0000278	mitotic cell cycle	66	9.25E-07
Cluster 5 (enrichment score: 5.80)
GO:0000226	microtubule cytoskeleton organization	36	2.82E-07
GO:0007017	microtubule-based process	49	2.81E-06
GO:0007010	cytoskeleton organization	72	5.08E-06
Cluster 6 (enrichment score: 5.77)
GO:0030198	extracellular matrix organization	32	5.00E-09
GO:0043062	extracellular structure organization	34	2.52E-05
GO:0030199	collagen fibril organization	12	4.00E-05

Clusters with more than five GO terms are represented by the most significant five

ISSN: 1471-2164