Table 3 IPA summary of RNA-Seq analysis of abdominal fat in HG and LG cockerels (7 wk)
Top Canonical Pathways | p-value | Overlap | Ratio |
|---|---|---|---|
Axonal Guidance Signaling | 1.07E-11 | 20.3% | 88/434 |
Acute Phase Response Signaling | 4.80E-11 | 27.2% | 46/169 |
Role of Tissue Factor in Cancer | 4.05E-10 | 30.9% | 34/110 |
Coagulation System | 4.13E-09 | 48.6% | 17/35 |
Complement System | 1.20E-08 | 45.9% | 17/37 |
Top Upstream Regulators | p-value of overlap | #Target Genes | |
ESR1 | 6.70E-29 | 234 | |
TP53 | 1.48E-24 | 230 | |
CTNNB1 | 4.21E-19 | 132 | |
ESR2 | 1.14E-17 | 83 | |
SMARCA4 | 3.03E-13 | 105 | |
Top Molecular and Cellular Functions | p-value | # Genes | |
Cellular Movement | 7.08E-08 – 5.98E-43 | 538 | |
Cellular Growth and Proliferation | 7.49E-08 - 3.56E-37 | 866 | |
Cell Morphology | 1.37E-07 - 5.49E-35 | 606 | |
Cell Death and Survival | 1.31E-07 - 2.52E-30 | 706 | |
Cellular Assembly and Organization | 3.03E-08 - 2.15E-29 | 452 | |
Physiological System Development and Function | p-value | # Genes | |
Organismal Development | 1.40E-07 - 1.18E-29 | 701 | |
Tissue Development | 1.53E-07 - 9.90E-28 | 801 | |
Cardiovascular System | 1.47E-07 - 5.03E-27 | 373 | |
Embryonic Development | 5.07E-08 – 7.56E-25 | 476 | |
Organismal Survival | 8.82E-09 - 1.54E-24 | 530 | |
Top Up-regulated Genes | Log2 Ratio | Top Down-regulated Genes | Log2 Ratio |
MYL1 | 7.55 | GC | −8.52 |
SCD | 7.02 | FGB | −8.34 |
ACTN2 | 6.15 | PLG | −8.23 |
CASQ2 | 5.91 | AHSG | −8.18 |
TNNC2 | 5.72 | FGA | −8.14 |
MYH3 | 5.58 | HRG | −7.73 |
RIPPLY3 | 5.03 | FGG | −7.62 |
TNNI2 | 4.44 | ALB | −7.40 |
SMOC1 | 4.13 | APOH | −6.93 |
ABHD3 | 4.08 | KNG1 | −6.63 |