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Fig. 1 | BMC Genomics

Fig. 1

From: Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia

Fig. 1

Venn diagram showing the number of genes differentially regulated in the WT and Sphk1 −/− neonatal mice exposed to hyperoxia. Two-way ANOVA was performed to analyze the data. There are three variables in the two-way ANOVA performed here such as 1. knock out of Sphk1 gene, 2. hyperoxia, 3. interaction of Sphk1 −/− and hyperoxia. Red circle shows all the genes affected by knockout of Sphk1 gene (61 + 99 + 164 + 26 = 350). Sphk1 −/− shows 61 genes solely differentially regulated when the corresponding gene was knocked out. Orange circle shows all the genes (4074 + 868 + 99 + 164 = 5205) affected by hyperoxia. 4074 genes were differentially regulated by hyperoxia compared to the corresponding normoxic control unaffected by other factors. Green circle shows genes affected by the interaction between the two factors i.e., Sphk1 −/− and hyperoxia (673 + 26 + 164 + 868 = 1731). 673 genes were solely affected by the interaction between Sphk1 −/− and hyperoxia, independent of the direct impact of either

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