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Fig. 4 | BMC Genomics

Fig. 4

From: Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia

Fig. 4

Heatmap showing genes differentially regulated in the nodal pathway related to mostly DNA damage G2/M check point (cluster 3). The cluster combines data from 11 related pathways as shown in Additional file 2: Table S2. Selected genes depicted in the heatmap are described here. Among the genes prominently downregulated by hyperoxia in the WT are 1) Cyclins A, B and D, Cdk1, 2) ATM serine/threonine kinase, Chk1. ATM is activated by DNA double-strand breaks. In contrast, gene for Wee was upregulated in WT HO along with Gadd45 alpha

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