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Fig. 6 | BMC Genomics

Fig. 6

From: Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia

Fig. 6

Heatmap showing genes differentially regulated in the nodal pathway related to cluster 10. The cluster combines gene expression analysis data from glucocorticoid-induced elevation of intraocular pressure as glaucoma risk factor and cell adhesion and extracellular matrix remodeling. Among the genes downregulated in WT HO in contrast to Sphk1 −/− HO are those coding for basal lamina such as Laminin 1, 5 and Collagen IV, matrix metalloproteinases such as MMP-14, MMP-3 (Stromelysin-1) and integrin beta sub unit (ITGB). Laminin-5 and Stromelysin-1 are upregulated significantly in Sphk1 −/− HO. Genes significantly upregulated in WT HO are those coding for Cox 2, Serpina 3 and Plat. Cyclooxygenase (COX) catalyzes formation of prostaglandins such as prostacyclin. Serpina 3 gene codes for alpha 1-antichymotrypsin which inhibits the activity of proteases, and thereby protects tissues from proteolytic damage. Sphk1 −/− HO also revealed upregulation of Cox 2 and Serpina3 gene expression in response to hyperoxia

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BMC Genomics

ISSN: 1471-2164

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