Skip to main content
Fig. 8 | BMC Genomics

Fig. 8

From: Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia

Fig. 8

Heatmap showing genes differentially regulated in the nodal pathway related to Wnt signaling and epithelial mesenchymal transition (EMT) (cluster 11 b). The following genes related to EMT were downregulated in WT HO: alpha − V/beta − 1 integrin, fibronectin, vimentin, slug, Zo-1. Frizzled and Wnt signaling were also noted to be downregulated in WT HO. Gene for LIM Domain Kinase 2 (Limk 2) was upregulated in WT HO along with other genes described earlier. Limk2 is known to inactivate cofilin and induce formation of stress fibers and focal complexes

Back to article page