Table 3 Comparison of the current differential gene expression analysis to published human BPD microarray data. Human lung microarray had four groups such as early gestation control, late gestation control, early BPD and late BPD. Genes found to be differentially regulated in response to hyperoxia that are common to human and mouse neonatal lungs are presented here
Gene Symbol (Gene name) | Early Gestation Control Lungs | Late Gestation Control Lungs | Early Gestation Age BPD | Late Gestation Age BPD | WT HO Vs. RA (BPD equivalent) | SK HO Vs. RA (BPD protection) | Gene function |
|---|---|---|---|---|---|---|---|
CD177 (CD177 Molecule) | ↓ | ↓ | ↓ | ↑ | ↑ 2.26378 | ↑ 2.60461 | Neutrophil activation, transmigration |
IL1RL1(interleukin 1 receptor like 1) | ↓ | ↓ | ↑ | ↑ | ↑ 1.5 | No change | Mediates cytokine-induced immune and inflammatory responses. |
SFN (14-3-3 protein sigma) | ↓ | ↓ | ↑ | ↑ | ↑ 1.5 | No change | Promotes p53-regulated inhibitor of G2/M progression |
SH3RF2(SH3 Domain Containing Ring Finger 2) | ↓ | ↓ | ↑↑ | ↑ | ↑↑ 4.8 | ↑ 1.58 | Protein ubiquitination |
NNMT(Nicotinamide N-Methyltransferase) | ↓ | ↓ | ↑ | ↑ | No change | ↓ 1.71 | N-methylation of pyridines to form pyridinium ions |
LIPG (Lipase G, Endothelial Type) | ↓ | ↑ | ↑↑ | ↑ | No change | ↓ 3.29 | Molecular bridge between endothelial cells and lipoproteins. |
SELE (Selectin- E) | ↓↓ | ↓ | ↑↑ | ↑ | ↑ 2.28 | ↑ 1.3 | Recruits leukocytes to the site of injury |
ALDH1A3 (Aldehyde Dehydrogenase 1 Family Member A3) | ↓↓ | ↓↓ | ↑↑ | ↑ | ↑ 1.9 | ↑ 2.03 | Detoxification of aldehydes |
CH25H (Cholesterol 25-Hydroxylase) | ↓↓ | ↓↓ | ↑↑ | ↑↑ | ↑↑ 22.9 | ↑ 1.6 | Catalyze the hydroxylation of hydrophobic substrates. |
CXCL5 (CXCL5 or ENA78) | ↓↓ | ↓↓ | ↑ | ↑↑ | ↑ 3.57 | ↑ 3.26 | Recruit neutrophils, promote angiogenesis and remodel connective tissues |
MARCO (macrophage receptor with collagenous structure) | ↓↓ | ↓ | ↑↑ | ↑↑ | ↑ 2.18 | ↑ 2.45 | Part of the innate antimicrobial immune system |