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Table 1 Top 30 significantly DE miRNAs and their predicted target genes from microarray analysis in PMECs at 3 hpc with E. coli compared with unchallenged controls

From: MicroRNA expression profiling of porcine mammary epithelial cells after challenge with Escherichia coli in vitro

3 hpc with E. coli

  

Upregulated miRNA

Sequence (5′ - > 3′)

Downregulated target genes

 miR-29b

UAGCACCAUUUGAAAUCAGUGUU

BCOR, KLHDC7A

 miR-140

CAGUGGUUUUACCCUAUGGUAG

RAB40B

 miR-210

UUGUGCGUGCGACAGCGACUUC

RAB40B

 miR-101

UACAGUACUGUGAUAACUGAAG

EML5, HELLS, RBM12

 miR-29a

UAGCACCAUUUGAAAUCGGUU

CDC6, CYP26A1, DNAJA1, EML5, RNF2, TIMM44

 miR-24-star

GUGCCUACUGAGCUGAUAUCAGU

USP46

 miR-30b-star

CUGGGAGGUGGAUGUUUACUUC

BCOR

 miR-B6

AAGUGCCCGACGCGGGGAACGUG

ENC1

 let-7 g-star

CUGUACAGGCCACUGCCUUGC

DUSP6

 miR-125a-3p

ACAGGUGAGGUUCUUGGGAGCC

ARID5B, ID4, ITGB8, KIAA0182, NUAK1, PHF17, RAB40B, TOX, USP2, VGLL3, WDR35

Downregulated miRNA

Sequence (5′ - > 3′)

Upregulated target genes

 miR-371

ACUCAAAAAAUGGCGGCACUUU

SGSM1

 miR-548u

CAAAGACUGCAAUUACUUUUGCG

NFKBIA

 miR-5128

CAAUUGGGGCUGGCGAGAUGGCU

SGSM1

 miR-8-5p

CAUCUUACCGGGCAGCAUUAGA

ARHGAP28, HIVEP2, IFNAR2

 miR-259-star

CCACCGAUUUGGCAUGGGAUUGAC

SGSM1

 miR-3277

UGGGCAUGUUUCUGAAAUUCGAU

ARHGAP28, IFNAR2, IL1A, PPARG

 miR-4903

UACCCCGGUAGGCAUAGGUUG

GLRX, IL1RAP, MAP3K8, PLAUR

 miR-202

AGAGGCAUAGGGCAUGGGAAAA

ARHGAP28, CHL1, GLI3, HIVEP2, IFNAR2, JAG1, LIFR, MAP3K8, OSBPL3, P2RX4, RFFL, RMND5A, RNF19B, TEP1, TNFAIP3, TPM2, VPS37C, YPEL2

 miR-5100

UCGAAUCCCAGCGGUGCCUCU

OBFC1

 miR-2287

CUGGGACUGGUGGCAGCACUU

CLDN1, ITGAV, RNF19B

 miR3949

UGAUGUUGAGGCAAAAAUGUAG

CCDC152, RBM39, RFX1

 miR-885-3p

AGGCAGCGGGGUGUAGUGGAUA

BIRC3, DCUN1D3, HIVEP2, IL10RB, MAP3K8, TNFAIP3

 miR-2518

UCGAGCAGCGGGUCGAUCCGAGC

CYP1A1, JAG1

 miR-3042

GAGGGCAGAUUAUUUCUGAUAC

JAG1, LPIN1, YPEL2

 miR-4031-5p

CCCAAAGUGUCGGCGCAUAU

SGSM1, TNFAIP3

 miR-4317

ACAUUGCCAGGGAGUUU

NFKBIA

 miR-216b

AAAUCUCUGCAGGCAAAUGUGA

ETV5, PDLIM5

 miR-890

UACUUGGAAAGGCAUCAGUUG

EHF, FCHSD2, IL10RB, PLXND1, SGSM1, SLC4A7, TAP1

 miR394b-star

AGGUGGACAUAUUGCCAACA

ITGAV, JAG1

 miR-648

AAGUGUGCAGGGCACUGAU

HIVEP2, IFNAR2, JAG1, SGSM1

  1. MiRNAs with p < 0.05 and fold change >1.5 or < −1.5 are listed and sorted by fold change in descending order. TargetScan-predicted miRNA-mRNA pairs showing negative correlation in expression profile and energy-value of at least −25 kcal/mol
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BMC Genomics

ISSN: 1471-2164

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