Fig. 4From: A GJA9 frameshift variant is associated with polyneuropathy in Leonberger dogsRepresentative histopathology of the peroneal nerve from male Leonberger dog with polyneuropathy and heterozygous GJA9 genotype. Resin embedded peroneal nerve sections collected post-mortem from a 5 year old male intact Leonberger dog with clinical signs of polyneuropathy. a Toluidine blue-acid fuchsin stain showing loss of predominantly large myelinated fibers and qualitatively increased populations of small calibre nerve fibers. b Paraphenelenediamine stain for myelin showing thin but intact myelin sheaths in many small nerve fibers. For comparison, images (c, toluidine blue-acid fuchsin stain) and (d, paraphenelenediamine stain) are from the peroneal nerve of a 6 year old female neutered Leonberger dog that was negative for both the ARHGEF10 and GJA9 variants and without clinical signs of polyneuropathyBack to article page