Table 2 Mutations in pncA and the proteins of the special set selected and the best candidates from the global genome analysis by mutation that appeared to be statistically significant
PZAse (Rv2043c) | Metal Ion transporters | Efflux pumps | Reported proteins | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Isolate | Res PZA | Gene | Protein | Promoter | % of PZAse activity b | NicT | Ctpl | CtpE | Rv0194 | MppL11 | MmpL3 | MgtE | Rv0987 | MmpL13a | MmpL10 | Rv1348 | Rv3239c | Mez | Rv2994 | RpsA | GpsI | PstC2 |
CSV4519 | 1 | – | – | – | 100.00 | – | – | – | A968V | – | – | – | – | – | – | – | P548S | – | – | – | – | – |
CSV4644 | 1 | T152C | H51R | – | 0.02 | Y357C | – | – | – | – | E317Q | – | – | L830 V | – | – | A381V | – | – | |||
CSV5769 | 1 | C232A | G78C | – | 18.12 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
CSV10399 | 1 | A280G | F94 L | – | 55.18 | – | – | – | – | – | – | A77S | V83F | – | – | – | – | – | – | – | – | |
CSV11678 | 1 | G185A | P62L | – | NA | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
LE486 | 1 | T35G | D12A | – | 24.06 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
LE492 | 1 | T35G | D12A | – | 24.06 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
LN180 | 1 | A392C | V131G | – | NA | – | – | – | – | – | – | – | W797a | – | – | – | – | – | – | – | – | |
LN2358 | 1 | A545C | L182 W | – | NA | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
LN3756 | 1 | T403G | T135P | – | 0.05 | – | N355 K | – | – | – | – | – | – | – | L218 V | – | – | – | – | P96R | – | |
MDRDM260 | 1 | T403G | T135P | – | 0.05 | – | N355 K | – | – | – | – | – | – | – | L218 V | – | – | – | – | P96R | – | |
MDRDM627 | 1 | – | – | – | 100.00 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
MDRDM1098 | 1 | C145T | D49N | – | 0.12 | – | A1469P | – | A302T | – | E907A | – | – | – | – | – | – | – | M432 T | – | – | |
MDRMA2491 | 1 | T35C | D12G | – | 36.45 | – | – | – | – | – | – | S265G | – | – | – | – | – | – | ||||
ME1473 | 1 | A100C | Y34D | – | 53.59 | – | – | – | – | C263R | – | – | T142A | – | – | – | – | W214a | – | – | ||
TBDM425 | 1 | C145T | D49N | – | 0.12 | – | A1469P | – | A302T | – | E907A | – | – | – | – | – | – | – | M432 T | – | – | |
TBV5000 | 1 | – | – | – | 100.00 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | ||
TBV5362 | 1 | – | – | – | 100.00 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | ||
TBV5365 | 1 | – | – | – | 100.00 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SLM036 | 1 | A190C | Y64D | – | NA | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SLM040 | 1 | T170C | H57R | – | NA | – | – | – | – | – | – | – | – | – | – | – | – | D46E | – | – | – | W162G |
SLM056 | 1 | – | – | – | 100.00 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SLM060 | 1 | – | – | T-11C | c | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | ||
SLM063 | 1 | A416G | V139A | – | NA | – | – | A653E | – | – | – | – | W797a | – | – | – | – | – | – | – | – | – |
SLM088 | 1 | – | – | – | NA | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SLM100 | 1 | – | – | T-11C | c | – | M920I | – | – | – | – | – | – | – | – | – | V904I | – | – | – | – | – |