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Table 2 Statistically significant results of the analysis of longitudinal effect of continued smoking

From: The dynamics of smoking-related disturbed methylation: a two time-point study of methylation change in smokers, non-smokers and former smokers

CpG site

CHR

Gene or region

Cross-sectional coefficient

Longitudinal coefficient

Longitudinal coefficient p-value

Median methylations (CS vs NS) diverging or converging from baseline to follow-up

cg13184736

1

GNG12

−0.339

−0.019

1.36E-05

Div.

cg25189904

1

GNG12

−0.507

−0.016

1.26E-06

Div.

cg23079012

2

2p25.1

−0.887

0.039

3.82E-09

Con.

cg05575921

5

AHRR

−2.575

0.061

7.83E-05

Con.

cg09338136

5

AHRR

−0.156

0.011

5.29E-18

Con.

cg06126421

6

6p21.33

−0.697

−0.017

1.23E-08

Con.a

cg14753356

6

6p21.33

−0.237

−0.012

7.94E-07

Div.

cg12147622

10

10q22.1

−0.125

−0.012

8.05E-05

Div.

cg05875421

14

GPR68

−0.211

0.017

1.23E-05

Con.

cg15022400

15

TRIM69

−0.112

−0.012

3.37E-06

Div.

cg23161492

15

ANPEP

−0.306

−0.010

5.69E-05

Div.

cg07251887

17

LOC100130933

−0.132

−0.011

5.26E-07

Div.

cg25512107

17

RPTOR

−0.336

0.037

2.48E-08

Con.

cg15187398

19

MOBKL2A

−0.161

−0.010

8.51E-06

Div.

  1. CHR: chromosome of the CpG site; CS: current smokers; NS: never smokers
  2. amethylation levels are converging, but the longitudinal and cross-sectional coefficients are of the same sign
  3. Legend: Presented are the 14 CpG sites significant for the longitudinal coefficient in the continued smoking analysis. The longitudinal coefficient represents the difference in rate of change of methylation M-value between baseline and follow-up for the individuals who were smokers at both time points relative to the individuals who were never smokers at both time points. Also presented is the cross-sectional coefficient, which represents the difference in methylation at baseline for the same two groups. A CpG site is labelled as “diverging” if the median methylations between the two groups separate further from baseline to follow-up; a CpG site is labelled as “converging” if the median methylations between the two groups approach one another from baseline to follow-up