Table 3 Statistically significant results for the model incorporating both intensity and duration of smoking
CpG site | CHR | Gene or position | Intensity of smoking coefficient | Duration of smoking coefficient | Intensity of smoking coefficient p-value | Duration of smoking coefficient p-value | EWAS coefficient for CpG site |
|---|---|---|---|---|---|---|---|
cg09935388 | 1 | GFI1 | −1.15E-02 | −1.85E-02 | 9.21E-06 | 5.83E-03 | −5.18E-01 |
cg08709672 | 1 | AVPR1B | −5.78E-03 | 4.31E-04 | 1.01E-06 | 8.49E-01 | −1.98E-01 |
cg03329539 | 2 | 2q37.1 | −6.49E-03 | −2.87E-03 | 3.11E-05 | 2.63E-01 | −3.24E-01 |
cg05951221 | 2 | 2q37.1 | −1.08E-02 | −5.97E-03 | 3.75E-09 | 9.87E-02 | −6.68E-01 |
cg21566642 | 2 | 2q37.1 | −1.23E-02 | −7.27E-03 | 5.54E-07 | 1.35E-01 | −9.99E-01 |
cg01940273 | 2 | 2q37.1 | −8.37E-03 | −4.38E-03 | 2.28E-08 | 1.58E-01 | −6.16E-01 |
cg00501876 | 3 | CSRNP1 | −5.33E-03 | −1.89E-03 | 5.24E-06 | 3.29E-01 | −1.57E-01 |
cg19859270 | 3 | GPR15 | −7.45E-03 | −7.58E-03 | 4.19E-05 | 6.36E-03 | −3.02E-01 |
cg02657160 | 3 | CPOX | −7.25E-03 | −7.50E-03 | 2.45E-05 | 4.66E-03 | −1.79E-01 |
cg23576855 | 5 | AHRR | −1.59E-02 | −1.16E-02 | 9.81E-08 | 2.47E-01 | −1.00E + 00 |
cg05575921 | 5 | AHRR | −4.32E-02 | −1.78E-02 | < 2e-16 | 8.51E-02 | −2.38E + 00 |
cg26703534 | 5 | AHRR | −6.54E-03 | −1.34E-03 | 2.61E-07 | 5.70E-01 | −3.39E-01 |
cg25648203 | 5 | AHRR | −1.04E-02 | −6.48E-03 | 1.75E-07 | 1.02E-01 | −4.13E-01 |
cg21161138 | 5 | AHRR | −1.09E-02 | −7.39E-03 | 8.01E-09 | 3.69E-02 | −4.72E-01 |
cg02451831 | 7 | KIAA0087 | −6.99E-03 | −2.85E-03 | 3.05E-05 | 3.34E-01 | −1.74E-01 |
cg10750182 | 10 | C10orf105 | −3.78E-03 | −2.89E-03 | 4.20E-05 | 5.33E-02 | −1.27E-01 |
cg02743070 | 10 | ZMIZ1 | −4.56E-03 | −4.68E-04 | 2.30E-05 | 7.80E-01 | −8.71E-02 |
cg03450842 | 10 | ZMIZ1 | −4.54E-03 | −2.07E-03 | 5.93E-05 | 3.01E-01 | −1.52E-01 |
cg21611682 | 11 | LRP5 | −4.91E-03 | −1.35E-03 | 6.35E-06 | 5.14E-01 | −1.89E-01 |
cg11660018 | 11 | PRSS23 | −5.21E-03 | −4.93E-03 | 5.94E-05 | 7.83E-02 | −2.33E-01 |
cg13525276 | 14 | TSHR | 8.15E-03 | 4.73E-03 | 4.76E-05 | 1.68E-01 | 1.88E-01 |
cg18625627 | 14 | TSHR | 8.46E-03 | 4.39E-03 | 3.17E-05 | 2.08E-01 | 1.85E-01 |
cg01513913 | 14 | 14q32.33 | −4.72E-03 | −1.55E-03 | 3.25E-05 | 5.20E-01 | −1.09E-01 |
cg23594345 | 14 | 14q32.33 | −9.68E-03 | −1.49E-04 | 6.14E-05 | 9.73E-01 | −1.99E-01 |
cg01208318 | 14 | 14q32.33 | −8.63E-03 | −9.63E-04 | 4.21E-05 | 8.27E-01 | −2.18E-01 |
cg23161492 | 15 | ANPEP | −7.55E-03 | −9.10E-03 | 4.46E-05 | 3.95E-02 | −2.73E-01 |
cg13500388 | 16 | CBFB | −6.27E-03 | −2.77E-03 | 6.18E-06 | 2.16E-01 | −1.16E-01 |
cg10062919 | 17 | RARA | −3.41E-03 | −1.41E-03 | 1.84E-05 | 3.15E-01 | −8.87E-02 |
cg00968616 | 17 | CUEDC1 | 4.60E-03 | −1.90E-04 | 2.56E-05 | 9.10E-01 | 7.15E-02 |
cg03636183 | 19 | F2RL3 | −9.68E-03 | −7.95E-03 | 1.80E-06 | 1.18E-01 | −6.63E-01 |
cg15159987 | 19 | CPAMD8 | −5.66E-03 | 2.20E-03 | 3.70E-06 | 2.97E-01 | −1.66E-01 |
cg21473814 | 19 | CRTC1 | 7.35E-03 | 4.00E-03 | 3.83E-05 | 2.16E-01 | 1.93E-01 |
cg11554391a | 5 | AHRR | −5.25E-03 | −1.58E-02 | 9.14E-03 | 2.13E-05 | −2.20E-01 |