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Table 1 Frequency of KEGG Orthologs in the imputed metagenome of the murine nasal microbiome calculated using Tax4Fun

From: IL-17 signalling restructures the nasal microbiome and drives dynamic changes following Streptococcus pneumoniae colonization

KEGG Orthology Classification

Abundance of mapped genes, % (IQR)

q value

Wild Type

IL-17RAKO

Metabolism

 Carbohydrate metabolism

13.16 (0.6)

13.59 (0.16)

0.27

 Energy Metabolism

7.22 (1.14)

6.35 (0.37)

0.24

 Lipid metabolism

3.48 (0.36)

3.45 (0.04)

0.71

 Nucleotide metabolism

6.27 (0.38)

6.54 (0.43)

0.27

 Amino acid metabolism

11.25 (0.39)

10.78 (0.35)

0.27

 Metabolism of other amino acids

2.69 (0.08)

2.73 (0.09)

0.27

 Glycan biosynthesis and metabolism

2.85 (0.13)

3.36 (0.26)

0.0016

 Metabolism of cofactors and vitamins

8.28 (2.01)

7.63 (0.22)

0.45

 Metabolism of terpenoids and polyketides

2.89 (0.15)

2.40 (0.17)

0.0074

 Metabolism of other secondary metabolites

0.767 (0.08)

0.651 (0.09)

0.0016

 Xenobiotics degradation and metabolism

3.41 (0.78)

2.78 (0.43)

0.039

Genetic information processing

 Transcription

0.275 (0.04)

0.273 (0.04)

0.75

 Translation

5.95 (0.76)

6.05 (0.97)

0.69

 Folding, sorting and degradation

2.75 (0.33)

2.87 (0.27)

0.28

 Replication and repair

5.55 (0.65)

5.71 (0.62)

0.56

Environmental information processing

 Membrane transport

11.09 (1.59)

12.51 (0.5)

0.13

 Signal transduction

5.60 (1.17)

5.61 (1.09)

0.77

 Signaling molecules and interaction

0.000276 (0)

0.000106 (0)

0.025

Cellular processes

 Transport and catabolism

0.266 (0.07)

0.259 (0.02)

0.68

 Cell motility

1.27 (0.6)

1.03 (0.62)

0.28

 Cell growth and death

1.52 (0.08)

1.39 (0.04)

0.0016

Human disease

 Infectious Diseases: Bacterial

1.84 (0.14)

2.42 (0.29)

0.0019

  1. Differences were analysed using Mann-Whitney tests corrected for multiple comparisons using the method of Benjamini, Krieger and Yekutieli with a false discovery rate of 1%. Significant differences between Wild type and IL-17RAKO animals are shown in bold ( q value < 0.01)