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Table 2 The frequencies of detected resistance alleles in each of the 4 patients after drug resistance. None of these mutations were observed (below detection limit) in the populations prior to development of resistance

From: Single-virion sequencing of lamivudine-treated HBV populations reveal population evolution dynamics and demographic history

#

Mutation

Pooled Deep Seq

BAsE-Seq

PacBio

P1

M204 V

L180 M

M204I

0.525

0.560

0.457

0.711

0.752

0.251

0.567

0.611

0.358

P2

M204I

0.978

0.882

0.990

P7

M204 V

L180 M

 

0.870

0.946

 

P11

M204I

L180 M

 

0.948

0.679

 
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BMC Genomics

ISSN: 1471-2164

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