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Table 2 MIC (μg/ml) of different antibiotics for B. cenocepacia J2315, D4, D4(pEP_RND4_operon), D4(pEP_RND2_operon), J2315(pEP_RND4_operon), J2315(pEP_RND2_operon), D4/C18 and D4/C20 strains

From: Subfunctionalization influences the expansion of bacterial multidrug antibiotic resistance

B.cenocepacia strain

Quinolones/Fluoroquinolones

Aminoglycosides

Ansamycins

β_lactams

Macrolides

Tetracyclines

Drug against mycobacteria

Others

CIP

LEV

NOR

SPAR

NAL A

KAN

STREP

AMP

ERY

TET

RIF

CHL

GRAM

NOV

J2315

4

8

16–32

8

16–32

2000

>4000

>4000

500

128

256

64

>512

16

D4

2

2

8

4

8

2000

4000

>4000

500

64

64–128

16

>512

<1

D4 (pEP_RND4_operon)

2–4

4

16

8

32

2000

4000

>4000

500

128

256

64

>512

16

D4 (pEP_RND2_operon)

4

4

16

4

64

2000

2000

>4000

500

64–128

128–256

128

>512

8

J2315 (pEP_RND4_operon)

8

8

32

8

32

2000

4000

>4000

500

128

256

128

>512

32

J2315 (pEP_RND2_operon)

4

8

16

8

32

2000

4000

>4000

500

128

256

64

>512

16

D4/C18

8

8

128

4

256

2000

4000

>4000

500

64

64–128

512

>512

64

D4/C20

8

8

32

4

256

2000

4000

>4000

500

64

64–128

512

>512

64

  1. Abbreviation: CIP ciprofloxacin, LEV levofloxacin, NOR norfloxacin, SPAR sparfloxacin, NAL A nalidixic acid, KAN kanamycin, STREP streptomycin, AMP ampicillin, ERY erythromycin, TET tetracycline, RIF rifampicin, CHL chloramphenicol, GRAM gramidicin, NOV novobiocin
  2. Strains information: D4 = ΔRND4 operon; D4 (pEP_RND4_operon) = D4 with the addition of RND4 operon, D4 (pEP_RND2_operon) = D4 with the addition of RND2 operon, J2315 (pEP_RND4_operon) = J2315 with the addition of RND4 operon, J2315 (pEP_RND2_operon) = J2315 with the addition of RND2 operon, D4/C18 and D4/C20 = D4 derived mutant strains, selected on CAF