Fig. 1

Procedure to identify genomic regions of interest based on the distribution of Strain-Specific Variants (SSV) across the genome. a SSVs were obtained for the pairwise comparisons between the two susceptible Lyon strains (LH or LL) relative to the control Lyon rat (LHvsLN and LLvsLN) and the reference rat genome (LHvsBN and LLvsBN). b Densities of SSVs were calculated in non-overlapping genome windows of 10kbp; we applied a smoothing algorithm to these densities (see Methods). c Distribution of the smoothed densities of SSVs obtained from LNvsBN and LLvsBN were used to calculate the threshold between HVRs and LVRs. Only those regions with at least three consecutive genome windows of the same type were considered. d HVRs and LVRs across chr19 for the hypertensive Lyon rat relative to the control Lyon rat (LHvsLN); regions showing poor mapping qualities (unmappable) were discarded from our analyses. Related Figure: Additional file 1: Figure S1