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Fig. 6 | BMC Genomics

Fig. 6

From: DNA methylation regulates discrimination of enhancers from promoters through a H3K4me1-H3K4me3 seesaw mechanism

Fig. 6

Scheme of how DNA methylation drives the seesaw mechanism between H3K4me1 and H3K4me3. CXXC binding domains including CFP1 and MLL1/2 are bound to unmethylated CpGs (right) and lead deposition of H3K4me3 (promoter mark), which results in RNA transcription. Increased DNA methylation (left) prevents binding of these CXXC domains, and the free nucleosomes can be bound by MLL3/4, which are not sensitive to methylation level, and transfer chromatin the enhancer mark H3K4me1. Decreased level of H3K4me3 due to DNA methylation coincides with a seesaw elevation of H3K4me1 and this is the mechanism behind positive correlation between DNA methylation and H3K4me1

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BMC Genomics

ISSN: 1471-2164

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