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Table 3 Summary of MHC-IIB variants, genetic divergence and codon-based Z tests for selection in R. japonica, R. ornativentris, and R. t. tagoi

From: Transcriptome analyses of immune tissues from three Japanese frogs (genus Rana ) reveals their utility in characterizing major histocompatibility complex class II

Species

No. of variants

Range of divergence within individual

Mean distance (nucleotide, amino acid)

Z-tests for selection for exon 2; Z statistic (p-value)

Z-tests for selection for exon 3; Z statistic (p-value)

 

Total

Per animal

Amino acid

Nucleotide

Amino acid

Exon 2

Exon 3

Neutrality

Purifying

Positive

Neutrality

Purifying

Positive

dN - dS

dS - dN

dN - dS

dN - dS

dS - dN

dN - dS

R. japonica

9

2–3

62

0.001–0.128

0.004–0.233

0.089, 0.179

0.044, 0.063

3.648 (0.0003)

−3.669 (n.s.)

3.641 (0.0002)

−2.543 (0.012)

2.563 (0.006)

−2.573 (n.s.)

R. ornativentris

11

1–2

74

0.001–0.158

0–0.262

0.107, 0.180

0.039, 0.044

0.746 (0.457)

−0.743 (n.s.)

0.751 (0.227)

−3.377 (0.001)

3.398 (0.0005)

−3.390 (n.s.)

R. t. tagoi

13

2

113

0.011–0.258

0–0.391

0.143, 0.235

0.066, 0.082

0.888 (0.376)

−0.887 (n.s.)

0.881 (0.190)

−3.247 (0.002)

3.334 (0.0006)

−3.262 (n.s.)

R. t. tagoi (excl Rata-01)

  

77

0.011–0.153

0–0.234

0.131, 0.220

0.037, 0.036

1.048 (0.297)

−1.049 (n.s.)

1.054 (0.147)

−3.411 (0.001)

3.438 (0.0004)

−3.386 (n.s.)

  1. #excluding insertions and deletions; n.s. – not significant, p = 1.000