Skip to main content
Fig. 1 | BMC Genomics

Fig. 1

From: Identification of placental nutrient transporters associated with intrauterine growth restriction and pre-eclampsia

Fig. 1

Strategy to target nutrient transporters in intrauterine growth restriction and pre-eclampsia using multiple approaches. The funnel like structure of the different analytical approaches represents the decreasing number of targets which overlap in every step of the analyses. Originating from 434 genes in meta-analysis of microarray data (1), 46 differentially expressed candidate genes were selected and clustered by STRING network (2). Gene expression screening of an in house placental tissue collection in the laboratory (3) was analysed by statistical evaluation and mathematical diagramming (4). The resulting 3 overlapping transporters were finally subjected to the biochemical analyses of protein translation and membrane localization

Back to article page