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Fig. 2 | BMC Genomics

Fig. 2

From: Identification of placental nutrient transporters associated with intrauterine growth restriction and pre-eclampsia

Fig. 2

Functional interaction networks of proteins encoded by the potential candidate targets. Forty six transporters selected from microarray analysis were clustered by Search Tool for the Retrieval of Interacting Genes (STRING). The protein-protein interaction in human placenta was performed using customized settings, including medium confidence of 0.4, Markov cluster algorithm (MCL) and 8 criteria for linkage (neighbourhood, gene fusion, co-occurrence, co-expression, experiments, databases, text mining and homology). The red, yellow and blue clusters highlight the substrate-specific components, which are vitamin transporters, microelements and ion transporters, and amino acid transporters, respectively. The available 3D protein structural information is embedded in the node, and the dashed lines represent the inter-cluster edges

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