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Fig. 1 | BMC Genomics

Fig. 1

From: The deregulated microRNAome contributes to the cellular response to aneuploidy

Fig. 1

miRNAome in aneuploid model cell lines. a Schematic summary of the work flow. b Heat map of significantly altered miRNAs in seven different aneuploid cell lines (adjusted p-value <=0.05). Blue indicates downregulation, red upregulation. Row and column dendrograms show Euclidean distance between miRNA expression profiles and cell lines, respectively. Commonly deregulated miRNA clusters are highlighted by black lines. c miRNA expression profile of miRNA cluster upregulated in all HCT116-derived aneuploid cell lines. d miRNA expression profile of miRNA cluster containing hsa-miR-10a-5p and hsa-miR-139-5p that are upregulated in 5 out of 7 sequenced aneuploid cell lines (red line). Grey lines indicate miRNAs in the same cluster that are not commonly deregulated. e miRNA expression profile of miRNA cluster containing hsa-miR-374b-5p that is down regulated in 6 out of 7 sequenced aneuploid cell lines (red line). Grey lines indicate miRNAs in the same cluster that are not commonly deregulated. Cell lines were ordered according to Euclidean distance. Asterisks indicate cell lines with H2B-GFP

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