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Fig. 4 | BMC Genomics

Fig. 4

From: The deregulated microRNAome contributes to the cellular response to aneuploidy

Fig. 4

microRNA target expression infers functional role of microRNAs. a Number of targets with a strong evidence for each deregulated microRNA annotated in the “Cellular Development, Cellular Growth and Proliferation” category in HCT116 5/4. The size indicates the number of targets, the colour shows the significance of microRNA deregulation. The microRNAs are presented according to their chromosomal location. b Target genes within the “Cellular Development, Cellular Growth and Proliferation” category and their mRNA and protein expression. Selected gene labels indicate targets with inverse miRNA-target expression that are associated with cell cycle processes. Shape indicates the type of experimental evidence for a microRNA-target interaction. The colour indicates log2 fold change microRNA expression. c Quantification of the protein levels of miRNA targets RCC2 and CDK4 in aneuploid and parental control cell lines. The quantification is based on four independent immunoblotting experiments, mean and standard deviation are shown

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