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Fig. 3 | BMC Genomics

Fig. 3

From: Transcriptional profiling of liver in riboflavin-deficient chicken embryos explains impaired lipid utilization, energy depletion, massive hemorrhaging, and delayed feathering

Fig. 3

A gene network found in liver of e15 embryos showing direct interactions of ligand-activated nuclear receptors and their direct target genes controlling “Lipid Metabolism” and “Molecular Transport” (a). Panel b shows the peroxisome proliferator activated receptor gamma (PPARG), itself an auto-regulated gene and 30 direct target genes identified by the Ingenuity® Knowledge Base. IPA predicts, according to accrued mammalian literature, that activated PPARG would lead to either activation (orange arrows) or inhibition (blunt blue edges) of its direct (AR-DE) target genes

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