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Table 3 Alignment of SM clusters predicted in A. tubingensis G131 with genome assembly of A. tubingensis CBS 134.48, A. niger CBS 513.88 and A. kawachii IFO 4308. cov: coverage; Id: Identity

From: Whole-genome sequencing of Aspergillus tubingensis G131 and overview of its secondary metabolism potential

Group

Cluster

Type

Size (Mb)

Similarity to known clusters

 

A. tubingensis

CBS 134.48

A. niger

CBS 513.88

A. kawachii

IFO 4308

Cov

(%)

Id (%)

cov (%)

Id (%)

cov (%)

Id (%)

Highly conserved

A. tubingensis A. niger

A. kawachii

Cluster 3

NRPS

45,6

 

99

98

97

87

99

94

Cluster 6

Terpene

21,3

 

90

96

93

86

100

92

Cluster 7

PKS

56,2

 

97

91

93

89

97

95

Cluster 9

PKS - Like

12,6

 

100

99

98

90

100

96

Cluster 13

PKS

37,7

 

99

98

84

85

99

92

Cluster 16

PKS

42,0

 

100

100

80

85

97

92

Cluster 17

PKS

51,9

 

100

99

91

86

99

94

Cluster 18

NRPS

61,9

 

98

99

81

91

88

95

Cluster 23

NRPS

62,7

Aflatrem (cov: 11%)

97

96

82

88

95

93

Cluster 24

NRPS

41,5

 

99

97

81

87

93

92

Cluster 25

NRPS / PKS

77,7

 

98

98

84

89

96

95

Cluster 29

NRPS-Like

50,4

 

99

99

85

92

93

96

Cluster 32

PKS

35,6

 

99

99

92

88

97

96

Cluster 33

PKS

48,0

 

95

98

80

90

92

94

Cluster 34

Terpene

22,0

 

99

96

98

90

99

95

Cluster 35

NRPS-Like

63,0

 

99

99

88

91

98

96

Cluster 36

PKS

50,5

 

100

99

97

90

99

95

Cluster 37

Terpene

22,1

 

99

98

88

89

99

94

Cluster 38

NRPS-Like

73,4

 

94

98

92

92

93

94

Cluster 39

NRPS-Like

54,8

 

100

99

96

90

99

96

Cluster 42

NRPS

47,2

 

100

98

95

89

98

95

Cluster 43

NRPS

44,0

 

98

97

85

87

97

95

Cluster 45

PKS

59,3

 

99

96

81

91

93

93

Cluster 49

PKS

68,4

 

97

95

80

88

95

96

Cluster 50

PKS

46,5

 

100

98

92

90

100

95

Cluster 52

PKS

83,8

 

99

96

84

85

98

94

Cluster 53

Terpene

21,6

 

100

98

96

87

99

95

Cluster 54

PKS

44,7

 

99

99

97

90

99

94

Cluster 56

PKS / NRPS

41,3

 

98

97

86

85

91

92

Cluster 62

Terpene

20,8

 

100

99

88

90

99

96

Cluster 63

NRPS-Like

56,8

 

99

99

93

90

98

95

Cluster 58

NRPS

77,8

 

100

99

85

83

89

91

Cluster 67

NRPS-Like

40,9

 

100

99

91

90

97

95

Cluster 69

Indole / DMAT

21,4

 

100

99

84

86

99

93

Cluster 74

NRPS

75,9

 

100

99

97

89

99

95

Cluster 77

NRPS

54,6

 

99

99

97

91

99

98

Highly conserved

A. tubingensis

A. kawachii

Cluster 1

PKS

46,8

 

100

99

50

91

97

95

Cluster 2

Indole / DMAT

21,5

Notoamide (cov: 20%)

97

97

77

89

93

94

Cluster 4

PKS

41,8

Fumonisin (cov: 31%)

100

99

54

81

92

90

Cluster 5

PKS

42,4

 

86

98

74

88

92

96

Cluster 10

Terpene

22,9

 

88

98

72

88

98

94

Cluster 11

NRPS-Like

42,7

 

100

99

74

93

94

92

Cluster 12

PKS

29,8

 

100

99

26

82

66

95

Cluster 15

NRPS-Like

54,5

 

100

99

79

85

89

93

Cluster 19

NRPS / PKS

71,4

 

98

99

43

89

86

97

Cluster 20

PKS

46,7

 

98

98

60

86

95

94

Cluster 22

PKS / NRPS

66,5

 

100

99

66

88

85

91

Cluster 26

PKS

40,9

 

100

99

67

83

81

92

Cluster 31

PKS

60,1

 

97

97

75

83

91

92

Cluster 40

Other

29,9

 

86

99

65

89

80

93

Cluster 41

PKS

45,3

 

96

99

68

91

91

93

Cluster 47

PKS

57,7

 

100

99

51

83

83

92

Cluster 51

NRPS / PKS

102,4

Stigmatellin (cov: 30%)

96

97

76

84

82

93

Cluster 55

NRPS-Like

53,8

 

85

96

69

89

87

95

Cluster 57

PKS

42,1

 

100

99

53

85

95

92

Cluster 60

PKS / NRPS

35,1

 

90

96

77

87

86

92

Cluster 64

PKS

70,4

 

99

97

78

83

95

93

Cluster 66

PKS / NRPS

63,0

 

100

99

71

88

95

92

Cluster 68

NRPS-Like

33,8

 

100

99

n.d.

n.d.

83

91

Cluster 70

NRPS-Like

52,8

 

100

99

51

83

84

91

Cluster 72

NRPS / PKS

43,8

 

100

99

15

81

85

91

Cluster 73

NRPS

45,7

 

99

99

59

88

82

91

Cluster 75

Terpene / PKS

50,7

 

100

99

76

92

94

94

Cluster 76

NRPS

45,5

 

99

97

75

87

97

92

Highly conserved

A. tubingensis

Cluster 8

NRPS / PKS

54,0

Isoflavipucine (cov: 12%)

100

99

61

95

25

97

Cluster 14

NRPS / PKS

66,2

 

100

99

42

86

60

94

Cluster 27

NRPS

73,4

 

100

99

51

90

60

95

Cluster 30

NRPS

59,6

 

87

99

58

86

75

93

Cluster 46

PKS / NRPS

60,7

Shanorellin (cov: 28%)

100

99

53

85

68

92

Cluster 48

PKS

47,9

 

97

97

58

82

78

91

Cluster 59

PKS

46,6

 

100

99

57

82

70

90

Cluster 61

NRPS / PKS

79,1

 

100

99

75

87

69

93

Cluster 65

NRPS

56,7

 

83

98

41

84

70

93

Specific to A. tubingensis G131

Cluster 21

PKS

82,5

Aflavarin (cov: 40%)

68

95

57

86

77

92

Cluster 28

PKS-Like

15,3

 

54

89

48

82

54

92

Cluster 44

PKS

32,8

TAN-1612 (cov: 80%)

71

96

75

89

72

92

Cluster 71

Terpene

20,3

 

76

98

65

86

76

93

Cluster 78

NRPS-Like

27,5

 

36

79

39

85

36

78

Cluster 79

Terpene

22,1

 

n.d.

n.d.

41

89

93

94

Cluster 80

PKS

24,1

 

n.d.

n.d.

30

93

64

88