Fig. 3

The microRNA signature responded to chow diet treatment in NASH mice. Mice were on 3H diet for 7 months for NASH development. Half of mice were switched to chow diet and were sacrificed on day 42 (3H_chow_42) or day 84 (3H_chow_84); half of mice were continued on 3H diet and were sacrificed on day 42 (3H_3H_42) or day 84 (3H_3H_84) as control. Lean mice were on standard chow diet and sacrificed together with the 3H_3H_84 group. a Principle component analysis of the microRNA signature in separating diet-switching animals (3H_chow_42, 3H_chow_84) from 3H mice (3H_3H_42, 3H_3H_84). b Scatter plots of miR-192 expression (reference to spike-in control) against histopathological scores: inflammation, macrovesicular vacuolation, perisinusoidal fibrosis and portal fibrosis