Table 2 Regulated canonical pathways in kidney
Canonical pathway | Regulation | p-value | Involved Genes |
|---|---|---|---|
Role of NFAT in Regulation of the Immune Response | L > M | 1.08E-05 | AKT3 (+ 1.49); CALM3 (− 1.25); CD3D (+ 1.59); CD3E (+ 1.52); FCGR3B (+ 1.64); GNAS (+ 1.33); GNG2 (+ 1.43); LCP2 (+ 1.69); NFATC2 (+ 1.51); PLCB3 (− 1.42); PLCB4 (+ 1.67) |
CCR5 Signaling in Macrophages | L<>M | 2.33E-05 | CALM3 (− 1.25); CCR5 (+ 1.76); CD3D(+ 1.59); CD3E (+ 1.52); GNAS (+ 1.33); GNG2 (+ 1.43); PRKCB (+ 1.55) |
PI3K Signaling in B Lymphocytes | L > M | 3.17E-05 | AKT3 (+ 1.49); CALM3 (− 1.25); CAMK2G (− 1.40); NFATC2 (+ 1.51); PLCB3 (− 1.42); PLCB4 (+ 1.67); PRKCB (+ 1.55); PTPRC (+ 1.86); VAV2 (− 1.37) |
Phospholipase C Signaling | L > M | 4.59E-05 | CALM3 (− 1.25); CD3D (+ 1.59); CD3E (+ 1.52); GNAS (+ 1.33); GNG2 (+ 1.43); LCP2 (+ 1.69); NFATC2 (+ 1.51); PLA2G6 (− 1.39); PLCB3 (− 1.42); PLCB4 (+ 1.67); PRKCB (+ 1.55); RHOJ (+ 1.56) |
Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis | L > M | 4.46E-04 | ADAMTS5 (+ 1.64); AKT3 (+ 1.49); CALM3 (− 1.25); CTSK (+ 1.54); FZD7 (+ 1.56); GSN (+ 1.64); IGF1 (+ 1.82); IL33 (+ 1.83); NFATC2 (+ 1.51); SPP1 (+ 2.36) |
Calcium Signaling | L < M | 7.26E-04 | ACTC1 (− 3.24); CALM3 (− 1.25); CAMK2G (− 1.40); GRIA3 (− 1.38); LETM1 (− 1.21); NFATC2 (+ 1.51); SLC8A1 (− 1.90) |
LXR/RXR Activation | L<>H | 3.10E-03 | ARG2 (− 1.48); SERPINF2 (− 3.08); TF (− 2.56) |
RhoGDI Signaling | L<>H | 8.12E-03 | ACTC1 (− 2.88); CDH2 (− 2.72); ESR1 (1.87) |