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Table 4 Statistically significant GSEA summary results in muscle of males and females (FDR < 0.05)

From: Gene co-expression networks in liver and muscle transcriptome reveal sex-specific gene expression in lambs fed with a mix of essential oils

 

KEGG pathway

Size

ES

NES

FDR

Males

Proteasome

34

−0.47

−3.14

0.000

Ecm Receptor Interaction

58

−0.35

−3.11

0.000

Complement and Coagulation Cascades

30

−0.41

−2.72

0.001

Spliceosome

95

−0.21

−2.32

0.012

Ribosome

36

−0.32

−2.31

0.009

Pyrimidine Metabolism

62

−0.24

−2.20

0.016

Antigen Processing and Presentation

32

−0.32

−2.15

0.020

Ppar Signaling Pathway

44

−0.26

−2.06

0.031

Rna Degradation

48

−0.25

−2.03

0.034

Peroxisome

60

−0.21

−1.96

0.046

Hematopoietic Cell Lineage

40

−0.27

−1.96

0.043

Ubiquitin Mediated Proteolysis

102

0.21

2.46

0.012

Basal Cell Carcinoma

29

0.37

2.39

0.012

Notch Signaling Pathway

37

0.33

2.33

0.015

Mapk Signaling Pathway

177

0.15

2.31

0.013

Wnt Signaling Pathway

96

0.19

2.18

0.025

Females

Peroxisome

60

−0.30

−2.77

0.000

Fatty Acid Metabolism

28

−0.41

−2.62

0.001

Spliceosome

95

−0.23

−2.61

0.002

Butanoate Metabolism

20

−0.47

−2.53

0.002

Proteasome

34

−0.36

−2.52

0.002

Pyrimidine Metabolism

62

−0.24

−2.23

0.011

Ribosome

36

−0.29

−2.09

0.025

Propanoate Metabolism

23

−0.36

−2.00

0.038

Valine Leucine and Isoleucine Degradation

35

−0.28

−1.96

0.043

Nucleotide Excision Repair

37

−0.27

−1.93

0.045

Lysine Degradation

33

−0.28

−1.93

0.042

Tryptophan Metabolism

21

−0.34

−1.91

0.043

Ecm Receptor Interaction

58

0.45

4.03

0.000

Complement and Coagulation Cascades

30

0.56

3.67

0.000

Focal Adhesion

159

0.20

2.89

0.000

Hematopoietic Cell Lineage

40

0.37

2.77

0.000

Regulation Of Actin Cytoskeleton

148

0.19

2.71

0.000

Lysosome

93

0.23

2.64

0.000

Pathogenic Escherichia Coli Infection

35

0.34

2.44

0.003

Cell Adhesion Molecules Cams

57

0.26

2.31

0.006

Endocytosis

128

0.17

2.30

0.006

Sphingolipid Metabolism

23

0.38

2.21

0.011

Cytokine Cytokine Receptor Interaction

88

0.20

2.16

0.015

Pentose Phosphate Pathway

19

0.40

2.04

0.030

Leukocyte Transendothelial Migration

74

0.19

1.93

0.051

Glycolysis Gluconeogenesis

32

0.28

1.93

0.048

  1. Size = Number of genes; ES Enrichment score. ES represents the overepresentation degree of top and bottom genes included in ranked list based on log2FoldChange of DE genes included; NES Normalized enrichment score