Fig. 2

Two examples of adversarial functional module (AFM) pairs. Each circle represents one gene. Edges show annotated PPIs in Reactome among genes in the two functional modules. Colors of circles show expression alteration scores. The upper panel shows the AFM pair M4-M14. Circles with grey border show genes in the network which participate in the pathway “RHO GTPases activates rhotekin and rhophilins”, with PPIs among them shown by the wider grey lines. The lower panel show the AFM pair M32-M39. Circles with grey border show genes which participate in the pathway “Clathrin-mediated endocytosis”. Interactions connecting genes participating in the pathway “Spry regulation of FGF signaling” are shown as blue lines, and interactions connecting genes in the pathway “EPH-ephrin mediated repulsion of cells” are shown as pink lines