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Fig. 4 | BMC Genomics

Fig. 4

From: Identification and characterization of functional modules reflecting transcriptome transition during human neuron maturation

Fig. 4

Applications of NMI/NFI in mouse brain neuron RNA-seq data to investigate neuron maturity dynamics. (A) Estimated dNMI of dissected single neurons in mouse medial ganglionic eminence (MGE) based on Chen et al. 2017 dataset. Each dot represents one cell, with color darkness showing maturity states estimated by dNMI. Darker color represents higher level of maturity. Cells are grouped based on the dissection time (x-axis) and cell groups identified by Chen et al. (y-axis). (B) Changes of neuron functionality indicated by neuron functionality index (NFI) in mouse purified neurons responding to neuroinflammation and neurodegeneration, based on Srinivasan et al. 2017 dataset. The left panel shows the estimated NFI, and the right panel shows the integrated NMI of immature-high modules. Each dot represents one purified neuron bulk sample, grouped by the treatment conditions

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